Eosinophilic Oesophagitis (EoE) What is EoE? Eosinophilic oesophagitis (e-o-sin-o-FILL-ik uh-sof-uh-JIE-tis) is a chronic immune system disease. With this disease, a type of white blood cell, called an eosinophil, builds up in the lining of the tube that connects your mouth to your stomach. This tube is also called the oesophagus. This buildup, which is a reaction to foods, allergens or acid reflux, can inflame or injure the oesophageal tissue. Damaged oesophageal tissue can lead to difficulty swallowing or cause food to get stuck when you swallow.Eosinophilic oesophagitis has been identified only since the early '90s, but is now considered a major cause of digestive system illness. Resources The informed patient bookletElimination diet for eosinophilic oesophagitis in adults