Barrett’s Oesophagus What is Barrett's Oesophagus? Barrett’s oesophagus is a change in the cellular structure of your oesophagus lining. It’s a risk factor for cancer, but the risk is low. It usually occurs in people with chronic, untreated acid reflux (GORD). Treating the underlying condition can help prevent Barrett’s esophagus from progressing to cancer. Clinical Practice Guidelines Clinical practice guidelines for the diagnosis and management of Barrett’s oesophagus and early oesophageal adenocarcinoma